Synthesis of (24R)- and (24S)-24,28-epoxyergost-5-en-3β-ols. Substrate stereospecificity in their metabolism in the insect Tenebrio molitor
- 1 January 1984
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 2039-2042
- https://doi.org/10.1039/p19840002039
Abstract
(24R)- and (24S)-24,28-Epoxyergost-5-en-3β-ols have been synthesized and their configuration at C-24 assigned. When these 24,28-epoxides were tritium labelled and fed in separate experiments to Tenebrio molitor larvae, only the (24R) stereoisomer was effectively converted into cholesterol, indicating that in this step of phytosterol metabolism the insect exhibits a high degree of substrate stereospecificity.This publication has 2 references indexed in Scilit:
- Substrate stereospecificity in the metabolism of fucosterol and isofucosterol 24,28-epoxides in Tenebrio molitorJournal of the Chemical Society, Perkin Transactions 1, 1981
- Mechanism of dealkylation of clionasterol in the insect Tenebrio molitorBiochemical Journal, 1978