Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity

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Abstract
Previous work showed that several relatively speci(r)c inhibitors of neuronal nitric oxide synthase (nNOS) produce protection against MPTP induced dopaminergic toxicity. We examined whether a highly speci(r)c novel inhibitor of nNOS, ARR1 7338, could also protect against MPTP toxicity. ARR17338 produced dose-dependent signi(r)cant protection against MPTP induced depletion of dopamine and protected against MPTP induced depletions of tyrosine hydroxylase immunostained neurons in the substantia nigra. These results provide further evidence that inhibitors of nNOS may be useful for the treatment of Parkinson's disease.