Morphological Lesions in Guinea Pigs during Skin Exposure to 1,1,2‐trichloroethane

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Abstract
Guinea pigs were exposed to 1,1,2-trichloroethane applied directly on the skin of the back for periods between 15 min-12 h under anesthesia. Morphological changes could be observed in the epidermis after 15 min and continued to progress during continuing exposure. The changes consisted of pyknotic nuclei, perinuclear edema of basal and suprabasilar cells as well as a focal separation of the epidermis from the corium with vesicle formations. The liver tissue showed reduction of glycogen content as well as hydropic changes in the centrilobular areas 6 h after the start of exposure. The liver changes were less marked 12 h after exposure and absent in nonanesthetized animals. No morphological changes were observed in the kidney or brain. 1,1,2-Trichloroethane (vinyl trichloride) is used in some countries as a raw material in the synthesis of vinylidene chloride (1,1-dichloroethylene) and as a solvent for chlorinated rubber and in laboratory work.