Interleukin‐HP1‐related hybridoma and plasmacytoma growth factors induced by lipopolysaccharide in vivo
- 1 January 1987
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 17 (8) , 1217-1220
- https://doi.org/10.1002/eji.1830170821
Abstract
Serum of lipopolysaccharide (LPS)‐treated mice was found to support the growth of interleukin‐HP1 (HP1)‐dependent hybridoma and plasmacytoma cell lines. This growth‐promoting activity, which was undetectable in normal serum, rose more than 1000‐fold within 2 h after i.v. injection of the toxin and disappeared in less than 1 day. It could be traced to a single component, which behaved like HP1 in sodium dodecyl sulfate‐polyacrylamide gel electrophoresis and reverse phase high performance liquid chromatography, and was completely inhibited by a rabbit anti‐HP1 antiserum. The LPS‐induced factor was apparently not of T cell origin, as indicated by the strong activity found in the serum of LPS‐treated nude mice. In vitro, LPS also considerably enhanced the production by macrophages of a factor with similar characteristics.This publication has 15 references indexed in Scilit:
- Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.The Journal of Experimental Medicine, 1987
- Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.The Journal of Experimental Medicine, 1987
- Interleukin 1 and poly(rI) · poly(rC) induce production of a hybridoma growth factor by human fibroblastsEuropean Journal of Immunology, 1987
- Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.Proceedings of the National Academy of Sciences, 1986
- A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in VitroScience, 1986
- Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin ResistanceScience, 1986
- Cloning and expression of murine interleukin-1 cDNA in Escherichia coliNature, 1984
- Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigensJournal of Immunological Methods, 1984
- Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cellsJournal of Cellular Physiology, 1976
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970