PROPRANOLOL PROTECTION IN ACUTE RENAL-FAILURE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 15  (5) , 401-403
Abstract
Activation of the renin-angiotensin system was previously implicated as one of the mechanisms involved in acute renal failure. Propranolol, a blocker of renin release, reduced the deleterious effect of ischemia on rat kidney function. Miniature electromagnetic flow probes measured blood flow after 70 min of total renal artery occlusion. Although brief infusion of propranolol reduced the degree of acute renal failure, it had no effect on renal blood reflow. The renin-angiotensin system apparently does not play a role in acute renal failure. Other explanations for the protective effect of propranolol are suggested.

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