The Effect of Lidocaine on Twitch Potentiation and Repetitive Neural ActivityProduced by Soman and Neostigmine

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Abstract
Soman and neostigmine produce twitch potentiation in the isolated rat phrenic nerve – diaphragm preparation by initiating repetitive electrical activity at neuromuscular junctions. This is associated with repetitive impulses in the phrenic nerve. Lidocaine abolishes the repetitive firing in both the phrenic nerve and diaphragm. This effect is produced by concentrations of lidocaine that have no effect on normal neuromuscular function as indicated by the absence of an effect on normal twitch or tetanic responses. These results indicate that the mechanism by which lidocaine abolishes drug-induced twitch potentiation involves the presynaptic nerve terminals.

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