Octreotide Effects on Orthostatic Hypotension in Patients with Multiple System Atrophy
- 1 February 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Clinical Neuropharmacology
- Vol. 18 (1) , 83-89
- https://doi.org/10.1097/00002826-199502000-00012
Abstract
In nine patients with orthostatic hypotension due to multiple system atrophy, the effects of octreotide (100 micrograms s.c.), a somatostatin analogue, on blood pressure (BP), heart rate (HR), and norepinephrine (NE) plasma levels after 60 degrees head up tilt test were evaluated by a randomly controlled study. Octreotide increased supine BP, tilt-test duration (+28%), and delay to obtain minimal BP during the 60 degrees head up tilt (+50%). Octreotide changed neither HR nor NE plasma levels.Keywords
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