BODY-FLUID COMPARTMENT CHANGES DURING BURN SHOCK IN THE GUINEA-PIG

  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (4) , 457-466
Abstract
The alterations in body fluid compartments 1,4 and 8 h after a 70% full-skin thickness burn were studied in conscious guinea pigs. Hemodynamic changes associated with the burn were measured. Cardiac output and heart rate were depressed 1 h postburn and mean arterial blood pressure was depressed 8 h postburn. A hemoconcentration 1 h postburn as evidenced by an increase in hematocrit was due exclusively to loss of plasma volume. Red blood cell volume remained constant after the burn. As a consequence of decreased plasma volume total blood volume was depressed. Extracellular fluid was decreased 1 h after the burn; 4 and 8 h postburn extracellular fluid space was comparable to that in the control group. Total body water and body weights of burned animals did not differ from control values. The very rapid redistribution of fluids in burn shock without a loss of fluids from the body was demonstrated.

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