An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo
Open Access
- 28 July 2008
- journal article
- extracellular mediators-and-effector-molecules
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 84 (4) , 1101-1108
- https://doi.org/10.1189/jlb.0108061
Abstract
Journal of Leukocyte Biology considers manuscripts of original investigations focusing on the origins, developmental biology, biochemistry and functions of granulocytes, lymphocytes, mononuclear phagocytes, and other cells involved in host defense. These include full-length papers on original research, rapid communications of new discoveries, letters, commentaries, and invited reviews.Keywords
Funding Information
- National Institutes of Health (NIH RO1-AI37113)
- European Union FP6
- Innochem (LSHB-CT-2005-518167)
This publication has 36 references indexed in Scilit:
- Anti–MCP-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and Attenuates Vein Graft Thickening Both In Vitro and In VivoArteriosclerosis, Thrombosis, and Vascular Biology, 2006
- A randomized controlled trial with an anti‐CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritisArthritis & Rheumatism, 2006
- eae36, a Locus on Mouse Chromosome 4, Controls Susceptibility to Experimental Allergic Encephalomyelitis in Older Mice and Mice Immunized in the WinterGenetics, 2006
- Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitisAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
- CCL2 and CCL5 mediate leukocyte adhesion in experimental autoimmune encephalomyelitis—an intravital microscopy studyJournal of Neuroimmunology, 2005
- Targeting CCR2 or CD18 Inhibits Experimental In-Stent Restenosis in PrimatesCirculation Research, 2002
- Chemokine receptors: multifaceted therapeutic targetsNature Reviews Immunology, 2002
- ChemokinesImmunity, 2000
- Bindarit retards renal disease and prolongs survival in murine lupus autoimmune diseaseKidney International, 1998
- Extension of Recombinant Human RANTES by the Retention of the Initiating Methionine Produces a Potent AntagonistJournal of Biological Chemistry, 1996