Correspondent reaction of mitotic recombination in yeast and sister chromatid exchange in human lymphocytes
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 181 (1) , 147-149
- https://doi.org/10.1007/bf00339019
Abstract
In the lower eukaryote Saccharomyces cerevisiae, 4,5,6-trichloro-2-(dichlorophenoxy)phenol and acridine orange cause different specific genetic alterations, either gene mutations or recombinations. These specific effects were used to characterize the mechanism of sister chromatid exchange (SCE) formation in human lymphocytes. Assuming that genetically active substances have comparable effects in lower and higher eukaryotes, the observations provide indirect evidence for a connection between induced mitotic recombination in yeast and SCEs in human lymphocytes and suggest that SCEs may be the consequence of a repair process.This publication has 17 references indexed in Scilit:
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