Cardiovascular and antiarrhythmic effects of aprindine (AC 1802) during partial occlusion of a coronary artery in the pig
- 1 July 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 11 (4) , 317-323
- https://doi.org/10.1093/cvr/11.4.317
Abstract
The effect of intravenously administered aprindine (AC 1802) as a prophylactic agent against ventricular arrhythmias was studied in pigs. During the first 30 min of ischaemia 5 of the 22 untreated animals died because of ventricular fibrillation against 1 of the 23 animals pretreated with aprindine (P=0.09). Ventricular tachycardias were observed in 10 untreated animals and in none of the aprindine group (P=0.0002). The incidence of other arrhythmias was significantly less in the aprindine group compared with the untreated group (P <0.02).Keywords
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