Peptide Contraception: Antifertility Properties of LH‐RH Analogues
- 1 September 1979
- journal article
- research article
- Published by Wiley in International Journal of Gynecology & Obstetrics
- Vol. 16 (5) , 359-372
- https://doi.org/10.1002/j.1879-3479.1979.tb00466.x
Abstract
A prototype LH-RH antagonist dampened the proestrous gonadotropin surge and blocked ovulation but had no effect on pregnant animals. In contrast, LH-RH and two highly potent LH-RH agonists terminated pregnancy when administrated prior to or following implantation. This contragestational effect, as well as other antireproductive properties of the agonists, coupled with the reversibility of their effects, strongly suggest that such peptides may provide a new basis for contraception.Keywords
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