Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers

13 June 1989

proceedings article
Published by SPIE-Intl Soc Optical Eng

Vol. 1065, 2-10
https://doi.org/10.1117/12.977998

Abstract

Various different photosensitizers were compared to Photofrin® II with respect to their potential for causing direct tumor cell inactivation and/or vascular damage. GaCl-phthalocyanine of mixed sulfonation, while being 10 x more efficient than Photofrin® II in tumor cell inactivation, caused equal vascular photosensitization. Monosulfonated AlC1-phthalocyanine, on the other hand, was sparing to the vasculature, while still exhibiting good tumor cell effects. Large differences in vascular photosensitization were also observed with tetra- and monosulfonated tetraphenylporphines.© (1989) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

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