Effects of lesions in the hypothalamus and amygdala on feeding behavior in the rat.

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Abstract
Lesions in the ventromedial hypothalamus (VMH) of 13 adult female albino Sprague-Dawley rats produced hyperphagia, obesity, and finickiness and decreased the latency to feed in a novel environment, a test which should be little influenced by VMH damage according to the satiety center hypothesis. A similar decrease in latency to feed was produced in controls by food deprivation. Lesions in the corticomedial amygdala (CMA) of 7 Ss inhibited feeding in a novel environment but did not influence ad-lib food intake in the home cage. The CMA-lesioned Ss performed like controls in tests of open-field activity and shuttle-box avoidance, indicating that an interpretation of the observed inhibition of feeding in terms of increased emotional reactivity is unlikely. 6 Ss with combined VMH and CMA lesions responded to food like VMH-lesioned Ss, suggesting that the influence of the amygdaloid mechanisms is mediated by the ventromedial hypothalamus. (23 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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