LEVELS OF CORTISOL, CORTICOSTERONE, CORTISONE AND 11-DEOXYCORTISOL IN THE PLASMA OF STRESSED AND UNSTRESSED SUBJECTS

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Abstract
The changes in the levels of corticosteroids varied among the 5 unstressed [human] subjects. Changes are in the concentrations of individual corticosteroids within each subject were not necessarily parallel. The level of cortisone seemed independent of the level of cortisol, even though most of the cortisone in the blood is probably formed by extra-adrenal oxidation of cortisol. The level of corticosterone seemed independent of that of cortisol even though both steroids are secreted by the adrenal cortex in response to ACTH. In the stressed subject, transient increases in the levels of cortisol, cortisone and 11-deoxycortisol occurred simultaneously after 4 min of exercise, but this parallel response did not persist during the recovery period. The level of cortisol reached its peak during recovery while that of cortisone remained relatively low. Although the level of corticosterone did not show the same pattern as the other steroids during exercise, the peak level coincided with that of cortisol 30 min after exercise. The level of corticosterone increased relatively more than did that of cortisol. Under unstressful as well as stressful conditions, the factors controlling the concentrations of each corticosteroid in the plasma do not act identically for each steroid.

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