A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development
Top Cited Papers
- 12 September 2008
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 321 (5895) , 1462
- https://doi.org/10.1126/science.1162525
Abstract
Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102–kilo–base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.Keywords
This publication has 5 references indexed in Scilit:
- Efficient mapping of mendelian traits in dogs through genome-wide associationNature Genetics, 2007
- Genetic Mapping of Canine Multiple System Degeneration and Ectodermal Dysplasia LociJournal of Heredity, 2005
- Expression of mouse Foxi class genes in early craniofacial developmentDevelopmental Dynamics, 2004
- Studies on Development of Hairless Descendants of Mexican Hairless Dogs and Their Usefulness in Dermatological Science.Experimental Animals, 1996
- Chinese crested dogJournal of Heredity, 1985