Structure-activity relationships in 1,2,3-triazol-1-yl derivatives of clavulanic acid.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (8) , 885-891
- https://doi.org/10.7164/antibiotics.37.885
Abstract
The synthesis of a series of analogs of clavulanic acid [an antibacterial antibiotic and .beta.-lactamase inhibitor], possesing a substituted 1,2,3-triazole ring in place of the exocyclic hydroxyl group, is described. Quantitative structure-activity relationships in this series are discussed.This publication has 2 references indexed in Scilit:
- Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, x-ray crystallography, and computer graphics in structure-activity analysisJournal of Medicinal Chemistry, 1982
- In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillinJournal of Antimicrobial Chemotherapy, 1980