The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5
- 4 December 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4832) , 1411-1413
- https://doi.org/10.1126/science.3479843
Abstract
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.This publication has 17 references indexed in Scilit:
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