Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (04) , 263-265
- https://doi.org/10.1055/s-1994-22820
Abstract
An improved synthesis of the azole antifungal building block (Figure), exemplified by a formal synthesis of Sch 45450, is described. Asymmetric induction was achieved by a modified Sharpless dihydroxylation (AD) reaction which generated products with excellent enantiomeric excess.Keywords
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