Detecting selection needs comparative data
- 19 January 2005
- journal article
- editorial
- Published by Springer Nature in Nature
- Vol. 433 (7023) , E6
- https://doi.org/10.1038/nature03222
Abstract
Arising from: J. B. Plotkin, J. Dushoff & H. B. Fraser Nature 428, 942–945 (2004); see also communication from Hahn et al.; Chen et al.; Plotkin et al. reply Positive selection at the molecular level is usually indicated by an increase in the ratio of non-synonymous to synonymous substitutions (dN/dS) in comparative data. However, Plotkin et al.1 describe a new method for detecting positive selection based on a single nucleotide sequence. We show here that this method is particularly sensitive to assumptions regarding the underlying mutational processes and does not provide a reliable way to identify positive selection.Keywords
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