A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone
- 31 July 1985
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 316 (6028) , 511-517
- https://doi.org/10.1038/316511a0
Abstract
The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was a potent inhibitor of prolactin secretion and stimulated the release of gonadotropins in rat pituitary cell cultures. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion in rabbits.Keywords
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