LYMPHOCYTE BLAST-TRANSFORMATION AND PERIPHERAL LYMPHOCYTE PERCENTAGES IN PATIENTS WITH SICKLE-CELL DISEASE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 10  (1) , 9-12
Abstract
Twenty patients with sickle cell disease (14 black females and 6 black males, mean age 31.5 .+-. 9.3) were studied by quantitating peripheral T [thymus-derived] and B [bone marrow-derived] lymphocyte percentages and measuring lymphocyte blast transformation (LBT) in response to phytohemagglutinin-P, concanavalin-A and pokeweed mitogen. Compared to normal black controls (19 black females and 1 black male, mean age 32.0 .+-. 9.2 yr) sickle cell patients had decreased T lymphocytes (50.2% .+-. 6.2 compared to 66.2% .+-. 1.7) and increased B lymphocytes (17.0% .+-. 3.4 compared to 7.7% .+-. 1.1). Sickle patients exhibited decreased LBT to all 3 mitogens.

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