Activities of a New Fluoroketolide, HMR 3787, and Its (Des)-Fluor Derivative RU 64399 Compared to Those of Telithromycin, Erythromycin A, Azithromycin, Clarithromycin, and Clindamycin against Macrolide-Susceptible or -Resistant Streptococcus pneumoniae and S. pyogenes
- 1 November 2001
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (11) , 3242-3245
- https://doi.org/10.1128/aac.45.11.3242-3245.2001
Abstract
Activities of HMR 3787 and RU 64399 were compared to those of three macrolides, telithromycin, and clindamycin against 175 Streptococcus pneumoniae isolates and 121 Streptococcus pyogenes isolates. HMR3787 and telithromycin were the most active compounds tested against pneumococci. Telithromycin and RU 64399 were equally active against macrolide-susceptible (MICs, 0.008 to 0.06 μg/ml) and -resistant S. pyogenes isolates, but HMR 3787 had lower MICs for ermB strains.Keywords
This publication has 24 references indexed in Scilit:
- Identification of an erm (A) Erythromycin Resistance Methylase Gene in Streptococcus pneumoniae Isolated in GreeceAntimicrobial Agents and Chemotherapy, 2001
- Two New Mechanisms of Macrolide Resistance in Clinical Strains of Streptococcus pneumoniae from Eastern Europe and North AmericaAntimicrobial Agents and Chemotherapy, 2000
- In Vitro Activity of the New Ketolide Telithromycin Compared with Those of Macrolides against Streptococcus pyogenes : Influences of Resistance Mechanisms and Methodological FactorsAntimicrobial Agents and Chemotherapy, 2000
- Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide PassageAntimicrobial Agents and Chemotherapy, 2000
- High prevalence of erythromycin-resistant, clindamycin/miocamycin-susceptible (M phenotype) Streptococcus pyogenes: results of a Spanish multicentre study in 1998Journal of Antimicrobial Chemotherapy, 2000
- Nationwide Survey in Italy of Treatment ofStreptococcus pyogenesPharyngitis in Children: Influence of Macrolide Resistance on Clinical and Microbiological OutcomesClinical Infectious Diseases, 1999
- Resistance ofStreptococcus pyogenesto Erythromycin and Related Antibiotics in ItalyClinical Infectious Diseases, 1998
- Antimicrobial activity of RU-66647, a new ketolideDiagnostic Microbiology and Infectious Disease, 1997
- Molecular cloning and functional analysis of a novel macrolide‐resistance determinant, mefA, from Streptococcus pyogenesMolecular Microbiology, 1996
- Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genesAntimicrobial Agents and Chemotherapy, 1990