Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate
- 1 January 1991
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 6 (4) , 288-292
- https://doi.org/10.1002/mds.870060404
Abstract
Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.Keywords
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