EFFECTS OF CHLORPROMAZINE, AZACYCLONOL AND CHLORDIAZEPOXIDE ON BRAIN CATECHOLAMINE CONTENTS OF STRESSED RATS

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Abstract
In the case of stress alone and without the administration of drugs, the brain nor -adrenaline level was raised significantly as compared with that in the physiological state. Chlorpromazine showed no significant effect on the brain noradrenaline level in normal situations, while it remarkably inhibited the elevation of the level in stressed state. Azacyclonol and chlordiazepoxide showed a little or no inhibition on the elevation of noradrenaline level. No adrenaline was detected in rat brains under all conditions, that is, stress alone, physiological, and stress after the pretreatment with various drugs, i.e., chlorpromazine, chlordiazepoxide and azacyclonol.