The mode of action of anabolic agents: the effect of testosterone on muscle protein metabolism in the female rat
- 1 November 1984
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 52 (3) , 515-521
- https://doi.org/10.1079/bjn19840119
Abstract
1. Testosterone (1 mg/kg body-weight per d) given subcutaneously to female rats increased their growth rate and food conversion efficiency but not their food intake compared with that of the placebo-oil controls. A higher dose of testosterone (10 mg/kg body-weight per d) failed to increase the daily weight gain.2. The increased growth rate of the testosterone-treated rats appeared to occur in the whole body and not specifically in muscle. There were no significant changes in body composition.3. The fractional synthetic rate of gastrocnemius muscle protein was higher in the hormone-treated rats than in controls. This contrasts with previous results for the anabolic agent trenbolone acetate and reflects differences in the mode of action of these two different steroids, both with androgenic properties.Keywords
This publication has 27 references indexed in Scilit:
- Effects of trenbolone acetate and zeranol on protein metabolism in male castrate andfemale lambsBritish Journal of Nutrition, 1983
- Protein synthesis in skin and bone of the young ratBritish Journal of Nutrition, 1983
- The effect of trenbolone acetate on growth rate and carcass composition of young female rabbitsAnimal Science, 1983
- Dietary protein intake and 3-methylhistidine excretion in the ratBritish Journal of Nutrition, 1980
- Effects of Anabolic Steroids on Hepatic Enzymes of Amino Acid CatabolismHormone and Metabolic Research, 1979
- The effect of trenbolone acetate with time on the various responses of protein synthesis of the ratBritish Journal of Nutrition, 1978
- Protein metabolism of rats treated with trienbolone acetateAnimal Science, 1978
- Protein turnover in rats treated with Trienbolone acetateBritish Journal of Nutrition, 1976
- Androgenization: Alterations in Uterine Growth and Morphology1Biology of Reproduction, 1975
- Morphology of the cells of normal, testosterone‐deprived and testosterone‐stimulated levator ani musclesJournal of Anatomy, 1966