UNTRADITIONAL GLUCOSE FERMENTING ACTINOMYCETES AS HUMAN PATHOGENS .2. ROTHIA DENTOCARIOSA AS A CAUSE OF ABDOMINAL ACTINOMYCOSIS AND A PATHOGEN FOR MICE

  • 1 January 1975
    • journal article
    • research article
    • Vol. 233  (1) , 80-92
Abstract
R. dentocariosa was a primary pathogen in a case of abdominal infection of a 19 yr old woman. Clinical findings were typical for actinomycosis and the patient was cured with penicillin following surgery. Actinomycotic granules were demonstrated in the pus by direct microscopy and R. dentocariosa was recovered as a single pathogen. Two morphologically distinct isolates recovered from primary cultures were described and recognized as physiologically identical varieties of a single organism. The varieties represented variability of the A-N type. The isolate was pathogenic for mice. I.p. infections provoked multiple nodule formation in the internal organs of experimental animals. The nodules were encapsulated, contained pus and microgranules of viable microbes, and tended to spread without regard to tissue. This 1st report of natural human infection caused by R. dentocariosa establishes this aerobic glucose fermenting actinomycete as an untraditional potential pathogen of human actinomycosis.

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