Hypocholesterolesmic Effect of 4,4′-(Isopropylidenedithio)-Bis(2,6-di-t-Butylphenol) (Probucol)
Open Access
- 1 September 1970
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 23 (9) , 1229-1233
- https://doi.org/10.1093/ajcn/23.9.1229
Abstract
Probucol (DH-581) is a lipophilic bisphenol that lowers serum cholesterol in several species. There is no effect on liver weight or liver cholesterol, and there is no consistent effect on serum and liver triglycerides. Incorporation of mevalonate-2-14C into cholesterol is not affected, indicating that probucol does not exert an influence on the late stages of biosynthesis. An inhibition of lipoprotein formation or transport is suggested.Keywords
This publication has 8 references indexed in Scilit:
- The effect of [4,4′-(isopropylidenedithio)bis(2,6-di-t-butylphenol)] (DH-581) on serum lipids and lipoproteins in human subjectsMetabolism, 1969
- Influence of a terminal period of fasting on the serum and tissue lipid effects of ethyl chlorophenoxyisobutyrate (CPIB)Metabolism, 1968
- The metabolism of di-(3,5-di-tert.-butyl-4-hydroxybenzyl) ether (Ionox 201) in the ratBiochemical Journal, 1967
- Effects of α-p-chlorophenoxyisobutyryl ethyl ester (CPIB) with and without androsterone on cholesterol biosynthesis in rat liverJournal of Lipid Research, 1965
- Agents affecting lipid metabolism—XV. Biochemical studies with the cholesterol biosynthesis inhibitor AY-9944 in young and mature ratsBiochemical Pharmacology, 1965
- Colorimetric Microdetermination of Plasma Free Fatty AcidsJournal of Pharmaceutical Sciences, 1964
- Studies of Cholesterol BiosynthesisPublished by Elsevier ,1960
- Studies on the biosynthesis of cholesterol. III. Purification of C14-cholesterol from perfusions of livers and other organsArchives of Biochemistry and Biophysics, 1952