Environmental Chemical-Induced Modification of Cell-Mediated Immune Responses

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Abstract
Technological advancement is accompanied by the development of many new chemical compounds followed by their dispersion, both intentional and accidental, throughout the biosphere. Although originally found in the environment at low, possibly harmless levels, many compounds are concentrated by biomagnification resulting in the exposure of mammals to potentially deleterious levels of the chemical compounds (26). In addition, certain mammalian tissues including primary lymphoid organs can concentrate dietary chemicals to levels well above those ingested (22), thereby resulting in exposure to concentrations above established maximal safety limits.