Acute Suppression of Circulating Testosterone Levels by Cortisol in Men*

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Abstract
The effect of acute activation of the ACTHadrenal axis on circulating testosterone (T) levels was investigated. Elevation of circulating cortisol resulting from insulininduced hypoglycemia or the administration of hydrocortisone was followed by a rapid decrease in serum T levels, without accompanying changes in LH or PRL. These findings suggest that hypercortisolism of endogenous or exogenous sources suppresses T secretion by a direct action on the testis. This adrenaltesticular axis may have biological implications on the reproductive adaptation to stress.

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