The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells

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Abstract
Pertussis toxin (PT) caused the ADP-ribosylation of a MW-41,000 protein on GH3 cell plasma membrane preparations. This effect, and muscarinic inhibition of prolactin release, were reversed at similar rates by pretreatment of intact cells with PT. Apparently the MW-41,000 protein is modified in intact GH3 cells, and this protein (a component of the putative Ni unit of adenylate cyclase) is involved in the expression of muscarinic inhibition.