HLA‐E and immunobiology of pregnancy
- 8 March 2006
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 67 (3) , 207-213
- https://doi.org/10.1111/j.1399-0039.2005.00550.x
Abstract
Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons.Keywords
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