Synthesis of Oxazolylindolyl Alkaloids via Rhodium Carbenoids

Abstract
The oxazolylindole alkaloids pimprinine (1a), pimprinethine (1b) and WS-30581 A (1c) are readily obtained in two steps by rhodium(II) catalysed reaction of N-Boc-3-diazoacetylindole with the appropriate nitrile followed by removal of the Boc-group.

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