EFFECT OF ESTROGENS ON THE BODY AND ORGAN WEIGHTS AND THE ARGINASE AND ‘ALKALINE’ AND ‘ACID’ PHOSPHATASES OF THE LIVER AND KIDNEY OF CASTRATED MALE MICE

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Abstract
Male mice castrated at 16.0-19.5 gs. body wt. were implanted subcut. with a pellet of pure estrone, equiline, estriol, [alpha]-estradiol, [alpha]-estradiol ben-zoate and [alpha]-estradiol dipropionate. The first 4 estrogens also were implanted as pellets consisting of 1 part of estrogen and 3 parts of cholesterol. After 30 days the mice were autop-sied. The addition of cholesterol to the estrogens decreased the rate of absorption about 300-400-fold. The estrogens increased the body wt. at the lower dose but inhibited or decreased it at the higher dose. The kidneys were not or only slightly increased in size. The thymus was decreased and the seminal vesicles and prostates were increased about the same by both doses of estrogens. The arginase activity of the kidney was increased equally by both dose levels. The arginase activity of the liver was not remarkably increased.

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