Itraconazole pharmacokinetics in patients with renal dysfunction
- 1 October 1988
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 32 (10) , 1595-1597
- https://doi.org/10.1128/aac.32.10.1595
Abstract
The single-dose pharmacokinetics of 200 mg of oral itraconazole were studied in seven uremic patients, seven patients treated by hemodialysis, and five patients treated by continuous ambulatory peritoneal dialysis. Plasma concentration-versus-time profiles showed wide intersubject variation. This study could not demonstrate any significant effect of renal dysfunction and hemodialysis or continuous ambulatory peritoneal dialysis treatment upon the pharmacokinetics of itraconazole, and firm conclusions concerning dosing in such patients should await confirmation of our data in a larger patient population.This publication has 4 references indexed in Scilit:
- Pharmacokinetics of itraconazole following oral administration to normal volunteersAntimicrobial Agents and Chemotherapy, 1988
- Azole antifungal agents: emphasis on new triazolesAntimicrobial Agents and Chemotherapy, 1988
- Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- Itraconazole: Pharmacologic Studies in Animals and HumansClinical Infectious Diseases, 1987