Platelet Antibody Tests in the Diagnosis of Purpura

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Abstract
PURPURA is a heterogeneous group of diseases with a single common denominator of spontaneous extravasation of blood. Classically, the purpuras are divided into two major classes: symptomatic and thrombopenic, depending on the presence or absence of a normal platelet count. The former is generally considered of allergic origin. Madison1 has advanced the concept that allergic factors may account for the vascular permeability that is present in both types of purpura. Yet the clinical manifestations are sharply different, since thrombopenic purpura presents the added problem of platelet deficiency, with its resultant coagulation defect and incomplete clot retraction.The present communication deals . . .