More complexity to the Bloom’s syndrome complex
- 15 October 2008
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 22 (20) , 2737-2742
- https://doi.org/10.1101/gad.1732808
Abstract
Bloom’s syndrome is caused by mutations in the BLM gene. The BLM gene product, BLM helicase, forms a complex with two other proteins, DNA topoisomerase IIIα and RMI1. In this issue of Genes & Development, Wang and colleagues (2843–2855) and Meetei and colleagues (2856–2868) report the discovery of a fourth component of this complex called RMI2. RMI2 may be a representative of a new family of OB-fold-containing proteins that are important for complex stabilization and checkpoint response.Keywords
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