The nature of somatic phase variation and its importance in the serological standardization of O-suspensions of Salmonellas for use in the Widal Reaction
- 15 May 1947
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 45 (2) , 111-117
- https://doi.org/10.1017/s0022172400013759
Abstract
1.Phase variation of the somatic antigen I inBact. paratyphosumA and of the component XII2inBact. typhosumand British strains ofBact. enteritidishas been confirmed.2. Strains ofBact. enteritidisisolated in India by blood culture from cases of invasive disease in man fall into two serological types, neither of which undergoes demonstrable somatic phase variation.3. The probable mechanism of this type of variation is discussed in the light of experimental findings.4. The effect which phase variation may have on the clarity of end-points in agglutinin titrations and on the serological standardization of Salmonella O-suspensions is demonstrated.5. The variation is briefly discussed from the points of view of Salmonella philogeny and of human Salmonella infection.I am indebted to the D.M.S. in India for permission to publish this paper.This publication has 13 references indexed in Scilit:
- The Demonstration of Non-specific Components in Salmonella paratyphi A by Induced VariationJournal of Bacteriology, 1941
- A Typhoid Variant and a New Serological Variation in the Salmonella GroupJournal of Bacteriology, 1941
- The Demonstration of Phase Variation in Salmonella abortus-equiJournal of Bacteriology, 1939
- Virulence of B. typhosus and resistance to o antibodyThe Journal of Pathology and Bacteriology, 1934
- The Small-flaking or “O” Agglutination of Permanent Standardised “O” Suspensions of B. typhosus by the Serums of Normal, Inoculated and Infected PersonsEpidemiology and Infection, 1928
- The use of Preserved Bacterial Suspensions for the Agglutination Test: With especial reference to the Enteric Fevers and Typhus FeversEpidemiology and Infection, 1928