Coagulation factors V and VIII and ceruloplasmin constitute a family of structurally related proteins.

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Abstract
Computer searches of the National Biomedical Research Foundation protein and nucleic acid sequence data bases using the NH2 terminus of the bovine factor Va 94-kilodalton H chain, the NH2 terminus of the 74-kilodalton factor Va L chain, and an internal 98-residue segment of porcine factor VIII revealed that both bovine factor V and porcine factor VIII are statistically homologous to human ceruloplasmin. The NH2-terminal segment of bovine factor Va H chain is homologous to 3 segments of ceruloplasmin sequence starting at residues 1, 351 and 713; the NH2-terminal sequence of bovine factor Va L chain is homologous to the same human ceruloplasmin sequence segments beginning at residues 1, 349 and 711. The longer porcine factor VIII sequence is homologous to 3 segments of human ceruloplasmin, residues 1-77, 400-433 and 683-791. The data indicate that factor V, factor VIII and ceruloplasmin comprise a group of evolutionarily linked protein structures that possibly resulted from multiplication of ancestral precursor genes.