Treatment of Digital Vasospastic Disease with the Calcium‐Entry Blocker Nifedipine

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Abstract
Eight patients with vasopastic disease of the digital arteries were treated with the Ca-entry blocker nifedipine (capsules), 10 mg t.i.d. [3 times/day] and 20 mg t.i.d. The degree of cold-induced digital vasospasm after local cooling of the finger to 15 and 10.degree. C, measured by strain-gauge technique, was significantly decreased by nifedipine. The degree of reduction was dose-dependent. All patients improved symptomatically. The side-effects of the drug were minor but became more prominent when the dose was increased. Thus, nifedipine is a useful agent in the treatment of digital vasospastic disease.