ANTIMICROBIAL THERAPY OF PULMONARY TUBERCULOSIS: REVIEW OF SIX YEARS' EXPERIENCE AT FITZSIMONS ARMY HOSPITAL

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Abstract
Summary data are presented on 875 patients with moderately or far advanced pulmonary tuberculosis treated during the past 6 yrs. with streptomycin, PAS, amithiozone, viomycin, terramycin, or isoniazid either alone or in various combinations. Combined antimicrobial therapy utilizing at least 2 of the 3 major antituberculous agents such as 1 or 2 g. of streptomycin every 3d day combined with 12 g. of PAS or 300 mg. of isoniazid daily until the stage of arrested or inactive disease, proved to be the most advantageous method of applying specific drug therapy. Amithiozone, viomycin or terramycin may be employed if the patient cannot tolerate, or has organisms resistant to, 2 of the 3 major drugs. Drug therapy is most effective against disease of recent origin. Although results of drug therapy are often dramatic there is general realization that it is frequently not definitive in a curative sense and must be integrated with an overall program of bed rest as well as medical or surgical measures as the individual case dictates.

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