SELECTIVE STAINING OF EXPERIMENTAL BRAIN TUMORS DURING LIFE

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Abstract
Intracerebral implantation of pellets of a carcinogenic agent (methylcholanthrene) in mice induced the growth of fibro-sarcomas, gliomas, and stratified squamous cell carcinomas after a period of 4-15 mos. Several of the induced fibrosarcomas and also a spontaneous mammary carcinoma were successfully transplanted into the brain and subcut. tissue of mice of the same strain. All of these tumor types were selectively stained when Nile blue was fed to the living animals. The gliomas were stained less intensely than the sarcomas, although in each of these types there was a sharp demarcation from the normal, unstained brain. The dye was diffusely distributed throughout the tumor tissue, but brain scars, normal brain, choroid plexus and cerebro-spinal fluid were never stained. The possible applications of this in vivo staining technic to aid in the diagnosis and treatment of human tumors are discussed.

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