EFFECTS OF 1-(2, 3, 4-TRIMETHOXY BENZYL)-PIPERAZINE DIHYDROCHLORIDE ON THE CARDIOVASCULAR SYSTEM IN THE RABBIT

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Abstract
It has been demonstrated in a variety of experimental animals that 1-(2, 3, 4-trimethoxy benzyl)-piperazine dihydrochloride (TBP) produces coronary vaso-dilation associated with a decrease in cardiac works (1). The cardiac effects of the compound resemble to those of nitrite derivatives in preventing the anginal attack in man by dilating the coronary vessels and also decreasing the cardiac works. The acute and chronic toxicity of the compound in mice and rats was very low and almost negligible (2). The present report deals with the pharmacodynamic effects on the circulatory system in rabbits, especially the preventing effects on the ECG changes in response to an intravenous injection of vasopressin.