Effect of Intra-Arterial Nitrogen Mustard Infusion on Wound Healing in Rabbits

Publisher Website
Google Scholar
Abstract
Results of this study show that a dose of 0.5 mg/kg administered over a 5-min. period has no effect if given at the time of wounding. If the same dose is given 3 days later, there is a marked reduction in the amount of granulation tissue and its collagen concentration and wound contraction is delayed until between the seventh and tenth days. Wounds protected by a tourniquet during nitrogen mustard infusion on the third day show no impairment of granulation tissue formation or collagen synthesis, but there is a retardation of wound contraction similar in time-course and extent to the unprotected wounds. Experiments designed to elucidate the mechanism of this selective effect on wound contraction suggest that it is brought about by residual circulating nitrogen mustard, or its degradation products, acting on a wound previously rendered lschemlc by a tourniquet.