Characterization of Lymphocytes Which Inhibit Proliferation of Human T Cells Exposed to Lymphocyte-Derived Mitogenic Factors

1 January 1979

journal article
Published by S. Karger AG in International Archives of Allergy and Immunology

Vol. 59 (2) , 192-198
https://doi.org/10.1159/000232258

Abstract

Culture supernatants of PHA-activated human lymphocytes (active SUPs) contain factors which are strongly mitogenic for fractionated peripheral T cells. This stimulation is suppressed by certain non-T lymphocytes. It is shown that these suppressor cells can inhibit an ongoing response of T cells to active SUP and that this inhibition is reversible. Using various rosette sedimentation techniques for fractionating subpopulations of lymphocytes it is concluded that the suppressor cells lack membrane-associated receptors for C′3 but possess receptors for the Fc part of IgG. This subset of lymphocytes may be an important regulator of lymphocyte proliferation during immune responses.

Keywords

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