THE INFLUENCE OF HEART RATE ON DIGOXIN‐INDUCED INHIBITION OF MYOCARDIAL NA+‐K+‐ATPASE ACTIVITY IN THE DOG
- 28 June 1981
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 8 (3) , 283-286
- https://doi.org/10.1111/j.1440-1681.1981.tb00161.x
Abstract
1. Groups of sedated dogs were studied at spontaneous heart rates (HR), 55-100/min, or at paced HR 200/min, with or without intravenous digoxin administration. After 60 min, active rubidium uptake (86 Rb+) of ventricular samples was determined in vitro. 2. Untreated fast and slow HR groups had similar uptakes. Following digoxin, 0.08 mg/kg, uptake was less at fast than slow HR (63.8, s.e.m. = 4.5 v. 87.5, s.e.m. = 5.0 pmol/mg LV/15 min, P less than 0.01). After 0.125 mg/kg, values were again lower in the fast HR group in which five of seven developed ventricular tachycardia. 3. Heart rate does not alter in vitro activity of myocardial Na+-K+-ATPase but does influence inhibition of the enzyme resulting from digoxin administration.Keywords
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