Structure-based design of carboxybiphenylindole inhibitors of the ZipA–FtsZ interaction

29 October 2003

journal article
research article
Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry

Vol. 1 (23) , 4138-4140
https://doi.org/10.1039/b312016c

Abstract

Structural features of two weak inhibitors of the ZipA–FtsZ protein–protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenylindoles with improved inhibitory activity.

Keywords

WEAK INHIBITORS
INTERACTION STRUCTURAL
STRUCTURAL FEATURES
KEY BINDING
CARBOXYBIPHENYLINDOLE INHIBITORS
FTSZ PROTEIN
NEW SERIES

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