Doxycycline Is Anti-Inflammatory and Inhibits Staphylococcal Exotoxin-Induced Cytokines and Chemokines

Open Access

1 November 2003

journal article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 47 (11) , 3630-3633
https://doi.org/10.1128/aac.47.11.3630-3633.2003

Abstract

Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.

Keywords

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