S-nitrosothiols and nitric oxide, but not sodium nitroprusside, protect nigrostriatal dopamine neurons against iron-induced oxidative stress in vivo
- 1 May 1996
- Vol. 23 (1) , 58-60
- https://doi.org/10.1002/(sici)1098-2396(199605)23:1<58::aid-syn7>3.0.co;2-g
Abstract
Intranigral infusion of ferrous citrate (4.2 nmol) induced an acute lipid peroxidation in the substantia nigra and a chronic dopamine depletion in the striatum of rat nigrostriatal system. Coinfusion of 8.4 nmol nitric oxide donors such as S‐nitroso‐glutathione (GSNO) and S‐nitroso‐N‐acetylpenicillamine (SNAP) or nitric oxide (∼2 nmol) protected nigrostriatal neurons against iron‐induced lipid peroxidation and associated oxidative injury. However, sodium nitroprusside (SNP, 8.4 nmol) augmented dopamine depletion caused by ferrous citrate because SNP is a ferricyanide complex. The present in vivo results indicate that nitric oxide and S‐nitrosothiols are antioxidants which can protect brain dopamine neurons against oxidant stress/damage.Keywords
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