Genetic and Environmental Factors in Cortisone Induced Cleft Palate

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Abstract
Susceptibility to cleft palate in the mouse appears to be under multigenic control. Perhaps 2 factors determining the degree of susceptibility to cortisone induced cleft palate are associated with the major histocompatibility complex (H-2) and certain dietary factors can modulate this susceptibility via a gene(s) which tentatively maps in the region of H-2D. Genetically controlled maternal effects and sexual dimorphism have been noted. The mechanism(s) by which the degree of susceptibility is determined is not clear, although at least 1 of the H-2 linked genes may control the number and/or avidity of cytoplasmic cortisone and corticosterone receptors as they do plasma testosterone levels and membrane receptors for insulin and glucagon.